Synthesis of geometrically defined exocyclic olefins

Autor:	Beth-Ann Badea, Chan Kou Hwang, Youssef L. Bennani, Laura J. Dar-ti, Stacie S. Canan Koch, Kristin S. Marron, Alex M. Nadzan
Rok vydání:	1996
Předmět:	chemistry.chemical_classification Olefin fiber Bicyclic molecule Chemistry Acetylide Organic Chemistry chemistry.chemical_element Biochemistry Combinatorial chemistry Catalysis chemistry.chemical_compound Drug Discovery Lithium Tricyclic
Zdroj:	Tetrahedron Letters. 37:8109-8112
ISSN:	0040-4039
DOI:	10.1016/0040-4039(96)01885-0
Popis:	The treatment of bicyclic and tricyclic ketones with lithium ethynyl acetylide, followed by the addition of a catalytic amount of CSA or p-TSA, affords the corresponding exocyclic olefinic ester in good yields, and geometric ratios up to 13:1 favoring the cis olefin. This procedure represents an addition to the repertoire of olefination methods and can readily be extended to other cyclic and acyclic systems.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f9731ceee4df41d56b9a8bc9817d23ac https://doi.org/10.1016/0040-4039(96)01885-0 Zobrazit plný text záznamu Full Text from ScienceDirect