CD4+ and CD8+ CD28nullT Cells Are Cytotoxic to Autologous Muscle Cells in Patients With Polymyositis
| Autor: | Vanessa Stache, Jayesh Pandya, Ingrid E. Lundberg, Lubna Al-Khalili, Vivianne Malmström, Andreas E. R. Fasth, Mohammad Shahadat Hossain, Paulius Venalis |
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| Rok vydání: | 2016 |
| Předmět: |
030203 arthritis & rheumatology
0301 basic medicine Pathology medicine.medical_specialty business.industry T cell Immunology CD28 chemical and pharmacologic phenomena hemic and immune systems medicine.disease Polymyositis 03 medical and health sciences Interleukin 21 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Rheumatology Cell culture medicine Immunology and Allergy Cytotoxic T cell Myocyte business CD8 |
| Zdroj: | Arthritis & Rheumatology. 68:2016-2026 |
| ISSN: | 2326-5191 |
| DOI: | 10.1002/art.39650 |
| Popis: | Objective. Inflammatory T cell infiltrates in the skeletal muscle tissue of patients with polymyositis are dominated by CD28-negative effector (CD28(null)) T cells of both the CD4 and CD8 lineage. ... |
| Databáze: | OpenAIRE |
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