Clinical aspects of pediatric Brugada syndrome

Autor:	H Huang, N Sumitomo, Y Kohjitani, Yuta Yamamoto, Takanori Aizawa, M. Horie, Tomohiko Imamura, Asami Kashiwa, Takeru Makiyama, Koichi Kato, Seiko Ohno, Jingshan Gao, Yimin Wuriyanghai
Rok vydání:	2020
Předmět:	medicine.medical_specialty biology Scn5a gene business.industry Syncope (genus) biology.organism_classification medicine.disease Sudden death Internal medicine Mutation (genetic algorithm) Ventricular fibrillation Cardiology Medicine Cardiology and Cardiovascular Medicine business Brugada syndrome
Zdroj:	European Heart Journal. 41
ISSN:	1522-9645 0195-668X
DOI:	10.1093/ehjci/ehaa946.0738
Popis:	Introduction Brugada syndrome (BrS) is an inherited arrhythmia characterized by a coved-type ST elevation and sudden death, especially in middle-aged males and more common in Asia. Mutations in SCN5A are detected in 15–20% and reported to be associated with poor prognosis. Among children, BrS is rare and the risk factors in pediatric BrS are unknown, especially in Asian population. Purpose The purpose of this study is to elucidate the risk factors for fatal arrhythmic events in Japanese pediatric patients with BrS. Methods We enrolled 52 Japanese children with BrS younger than 20 years, and performed genetic analysis and collected the clinical information. Results The mean age of initial symptoms was 10.7±5.5 years, and the mean follow-up period was 3.9±5.5 years. Ninety percent of patients were probands. No subjective symptom was confirmed in 28 of the patients, but aborted cardiac arrest (ACA) in 4, ventricular tachycardia in 4, ventricular fibrillation in 1, and syncope in 11. We identified mutations in SCN5A in 63%. There was no significant gender difference in ≤10 years, but a significant male predominance appeared in >10 years. And no gender difference was confirmed in the incidence of severe cardiac events in ≤10 years. Conclusion No gender difference was confirmed in ≤10 years in this study about Asian children. And being girls did not reduce the risk in ≤10 years. The frequency of SCN5A mutations was higher than adults, but decreased from childhood (68%) to adolescence (59%). In BrS, genetical and environmental factors may be more effective in childhood and adulthood, respectively. Funding Acknowledgement Type of funding source: None
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f96e1b08bf8374dd5079d7bc47458f1d https://doi.org/10.1093/ehjci/ehaa946.0738 Zobrazit plný text záznamu