Myocardial salvaging effects and mechanisms of metformin in experimental diabetes
| Autor: | Ipseeta Ray Mohanty, Ujwala Maheshwari, Manjusha K. Borde, Rajesh Kumar Suman, Y. A. Deshmukh |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Creatinine
medicine.medical_specialty endocrine system diseases medicine.diagnostic_test business.industry nutritional and metabolic diseases Renal function medicine.disease Streptozotocin Metformin chemistry.chemical_compound Endocrinology chemistry Diabetes mellitus Internal medicine Medicine Liver function Myocardial infarction business Lipid profile medicine.drug |
| Zdroj: | International Journal of Basic and Clinical Pharmacology. :341-349 |
| ISSN: | 2319-2003 |
| DOI: | 10.18203/2319-2003.ijbcp20160742 |
| Popis: | Background: Several epidemiological studies have found that in type II diabetic patients, Metformin improves vascular function and reduces cardiovascular events and mortality by mechanisms that are not entirely attributed to its anti- hyperglycemic effects; So far the effect of Metformin on experimentally induced myocardial infarction in setting of type II diabetic rats has not been studied. The aim of the present study was to investigate potential cardioprotective effects and mechanisms of Metformin subsequent to isoproterenol induced myocardial infarction in the setting of diabetes. Methods: Diabetes was induced with single dose of Streptozotocin (STZ): 45mg/kg ip and myocardial infarction was produced by administering isoproterenol (ISP): (85mg/kg, sc) to rats 24 and 48 h prior to sacrification (5th week). After the confirmation of diabetes on 7th day (Glucose>200mg/dl), Metformin (100 mg/kg) was administered and various parameters like anti-diabetic (Glucose, HbA1c), cardioprotective (CPK-MB, hs-CRP), metabolic (lipid profile, artherogenic potential), antioxidant (MDA) safety {pancreatic function (lipase), liver function (SGPT), kidney function (Creatinine) and histopathological indices of injury were evaluated in experimental groups. Results: Administration of STZ-ISP resulted in a significant decrease in body weight (p |
| Databáze: | OpenAIRE |
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