The use of genetic markers in predicting of oral lichen planus development and recurrence
| Autor: | E. Khusnutdinova, I. Gilyazova, E. Galimova, N. Chernyshova, G. Ron, S. Chuykin, G. Akmalova |
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| Rok vydání: | 2016 |
| Předmět: |
Pathology
medicine.medical_specialty integumentary system business.industry Disease Ethnic origin medicine.disease Dermatology stomatognathic diseases stomatognathic system Genetic marker Polymorphism (computer science) Healthy individuals Genotype Medicine Oral lichen planus Allele skin and connective tissue diseases business |
| Zdroj: | Actual problems in dentistry. 12:62-69 |
| ISSN: | 2412-9461 2077-7566 |
| DOI: | 10.18481/2077-7566-2016-12-1-62-69 |
| Popis: | To reveal the association of the interleukin 8 (IL-8) gene with the development and progression of oral lichen planus (OLP) we performed RT-PCR analysis of rs4073 polymorphism in the IL-8 gene in 92 oral lichen planus patients and 163 healthy individuals of Russian ethnic origin from the Volga-Ural region of Russia. The investigation showed the importance of polymorphism rs4073 of IL-8 gene for oral lichen planus development. The disease was associated with genotype rs4073*T / T which was found to be the genetic marker of high risk for oral lichen planus development, and rs4073*A / T genotype — the genetic marker of low risk for erosive-ulcerous oral lichen planus form development (p=0.016, OR=0.40) and the disease recurrence (p=0.02, OR=0.33). The results obtained in the investigation make a significant contribution to understanding the structure of hereditary predisposition to oral lichen planus development. |
| Databáze: | OpenAIRE |
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