ChemInform Abstract: ANTI-ULCER EFFECT OF ISOPRENYL FLAVONOIDS. III. SYNTHESIS AND ANTI-ULCER ACTIVITY OF METABOLITES OF 2′-CARBOXYMETHOXY-4,4′-BIS(3-METHYL-2-BUTENYLOXY)CHALCONE

Autor:	Sadakazu Yokomori, Ryuichi Saziki, Kazuaki Kyogoku, Yutaka Kawashima, Katsuo Hatayama
Rok vydání:	1985
Předmět:	Chalcone chemistry.chemical_compound chemistry Active compound Stereochemistry Sofalcone medicine Dihydrochalcone General Medicine medicine.drug
Zdroj:	Chemischer Informationsdienst. 16
ISSN:	0009-2975
DOI:	10.1002/chin.198536161
Popis:	Five dihydrochalcone derivatives, 2'-carboxymethoxy-4, 4'-bis (3-methyl-2-butenyloxy) dihydrochalcone (M-6-b), 2', 4-bis (carboxymethoxy)-4'-(3-methyl-2-butenyloxy) dihydrochalcone (M-2), 2', 4-bis (carboxymethoxy)-4'-(3-carboxy-2-butenyloxy) dihydrochalcone (M-1-a), 2', 4-bis (carboxymethoxy)-4'-(3-hydroxymethyl-2-butenyloxy) dihydrochalcone (M-1-b), and 2'-carboxymethoxy-4-hydroxy-4'-(3-methyl-2-butenyloxy) dihydrochalcone (M-4-b), which are the main metabolites in rats of a new anti-ulcer drug "sofalcone"(2'-carboxymethoxy-4, 4'-bis (3-methyl-2-butenyloxy) chalcone) were synthesized and the anti-ulcer activities of the major metabolites in humans, M-6-b, M-2, and M-1-a, were examined by Shay's and Takagi's methods and also by the use of rats with histamine-induced ulcer. The most active compound was M-6-b, which showed activity equal to or slightly weaker than that of sofalcone.
Databáze:	OpenAIRE
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