Effect of systemic administration of silver nanoparticles in treatment of experimental periodontitis in albino rats

Autor: Laila Sadek Ghali, Enas Hegazy, Waleed Mohamed Shaker
Rok vydání: 2021
Předmět:
Zdroj: Dental Science Updates. 2:175-184
ISSN: 2636-3844
DOI: 10.21608/dsu.2021.60867.1065
Popis: Introduction: Periodontal disease is one of the main dental diseases that affectmillions of people around the world. Modern nanotechnology progression andrenovations through nanodentistry providing a suitable solution for the treatment of manydental illnesses including periodontal disease. Aim: Histological and ultrastructuralevaluation of the effect of silver nanoparticles in treatment of periodontitis in albinorats. Materials and methods: A total of 18 adults male albino rats with body weightranging from 150 to 180 gm were used and divided into three groups group 1: served ascontrol, group 2: used for induction of experimental periodontitis using wiring aroundthe cervix of mandibular central incisors for two weeks, and group 3: after induction ofexperimental periodontitis as in group 2 they were subjected to intraperitoneal injectionwith silver nanoparticles for the treatment of periodontitis three times per week for fourweeks. Results: Histological and ultrastructural investigation revealed that periodontalligament around ligated mandibular incisors showed marked improvement in thedegenerated fibers after injection with silver nanoparticles in group 3 compared togroup 2 as the fibers regained their association in strong bundles and they regained theirattachment to regenerated bone and tooth surface. Conclusions: Marked regenerationof the periodontium of periodontally affected ligated mandibular incisors reflected thatsilver nanoparticles have a great anti-inflammatory effect
Databáze: OpenAIRE