Synthesis, characterization, in silico molecular modeling, anti-diabetic and antimicrobial screening of novel 1-aryl-N-tosyl-1H-tetrazole-5-carboxamide derivatives

Autor:	Gopalakrishnan Mannathusamy, Pazhamalai Srinivasan, Boobalan Maria Susai, Sekar Selvarasu
Rok vydání:	2021
Předmět:	Molecular model 010405 organic chemistry medicine.drug_class Aryl Carboxamide General Chemistry 010402 general chemistry Antimicrobial 01 natural sciences Combinatorial chemistry 0104 chemical sciences chemistry.chemical_compound chemistry Tosyl Docking (molecular) medicine Tetrazole ADME
Zdroj:	Chemical Data Collections. 32:100648
ISSN:	2405-8300
DOI:	10.1016/j.cdc.2021.100648
Popis:	Tetrazole carboxamide is one of the important categories of heterocyclic compounds that acquire a broad spectrum of biological and medicinal properties. The present work deals with the synthesis and characterization of some novel 1-aryl-N-tosyl-1H-tetrazole-5-carboxamide derivatives. All the synthesized compounds were characterized by FT-IR, 1HNMR, 13CNMR, elemental and mass spectrometric analysis. The compounds were evaluated for their in-vitro and in-vivo anti-diabetic and antimicrobial activity. Synthesized compound 3i 10 mg/kg exhibited maximum glucose lowering effect in diabetic rats compared to the other ten doses. All the synthesized compounds were evaluated in ADME properties and in-silico docking studies against proteins (PDB code-1E7U, 3KP3).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f950b02a47866a1fedb55920cfb37578 https://doi.org/10.1016/j.cdc.2021.100648 Zobrazit plný text záznamu Full Text from ScienceDirect