m-Coumaric acid attenuates non-catalytic protein glycosylation in the retinas of diabetic rats
| Autor: | Khalid O. Abulnaja, Mohammed Nihal Hasan, Tadao Asami, Maryam A Alghamdi, Taha A. Kumosani, Wesam H. Abdulaal, Fawzia A. ALshibili, Said S Moselhy, Abudukadeer Kuerban, Etimad A. Huwait, Syed Shoeb Razvi, Abdulrahman L. Al-Malki, Khadijah S. Balamash, Iman M. Ismail |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Protein glycosylation medicine.medical_specialty Glycosylation Antioxidant Health Toxicology and Mutagenesis medicine.medical_treatment Insulin M-coumaric acid medicine.disease 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine Endocrinology chemistry Glycation 030220 oncology & carcinogenesis Insect Science Internal medicine medicine Glycated hemoglobin Retinopathy |
| Zdroj: | Journal of Pesticide Science. 43:180-185 |
| ISSN: | 1349-0923 1348-589X |
| Popis: | In this study, we investigated the inhibitory effects of m-coumaric acid on the glycosylation of proteins in the retinas of diabetic rats. Male rats were divided into two main groups, Group I (normal control) and Group II (diabetic); Group II was further divided into four subgroups: Group IIa (diabetic control), Group IIb (diabetic rats were given m-coumaric acid orally [150 mg/kg, body weight (bw)/day]), Group IIc (diabetic rats were given HCA m-coumaric acid orally [300 mg/kg bw/day]), and Group IId (diabetic rats were given insulin [10 units/kg bw/day]) as a positive control). The treatment lasted for six weeks, and the data obtained suggested that m-coumaric acid reduced glucose and glycated hemoglobin levels, which further decreased the formation of glucose-derived advanced glycation end products. Hence, it protected the tissues from the detrimental effects of hyperglycemia and enhanced antioxidant activity. In conclusion, m-coumaric acid could be a potential candidate to prevent the onset and progression of retinopathy in diabetic patients. |
| Databáze: | OpenAIRE |
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