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The aim of this research was to investigate the industrialapplication of Sedum sarmentosum. Antibacterial activities of then-hexane, methylene chloride (MC), ethyl acetate, and n-butanolfractions of S. sarmentosum were tested against Escherichia coli,Staphylococcus aureus, and Helicobacter pylori. The MC fractionshowed the strongest antibacterial activity against E. coli, with aninhibition zone greater than 13 mm in disc assays. At 100 µg/mL,all fractions scavenged more than 50% of 1,1-diphenyl-2-picrylhydrazyl (DPPH) and hydroxyl radicals (·OH). In particular,the MC fraction showed the strongest scavenging activity againstDPPH and ·OH. In addition, we found that treatment with the MCfraction inhibited the growth of H. pylori and gastric adenocarcinomacells. The present results suggest that the MC fraction of S.sarmentosum would play the promising protective role againstpathogenic bacteria and free radicals.Keywords antibacterial · anticancer · antioxidant · free radical ·Sedum sarmentosum서론의학기술의 발달로 평균 수명이 연장되어 인구가 노령화된 반면, 식습관의 변화와 운동부족으로 각종 암, 고혈압 등 순환기계질환과 당뇨병, 간장 장애 등 만성 퇴행성 질환이 급증하고있다(NSOK, 2011). 이에 따라 여러 측면에서 노화억제와 건강유지를 위한 생리활성 물질에 대한 연구가 미생물과 식물분야에서 광범위하게 연구되고 있다(Goldberg, 1994; Sadaki, 1996).특히 H |
