Elastography in the Diagnosis of Pancreatic Malignancies
| Autor: | Jerzy Gil, Przemysław Dyrla, Krzysztof Kosik, Arkadiusz Lubas, Stanisław Niemczyk, Sebastian Czarkowski, Marek Saracyn |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test Receiver operating characteristic business.industry Area under the curve medicine.disease Malignancy Gastroenterology 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure 030220 oncology & carcinogenesis Internal medicine Medicine Adenocarcinoma Pancreatitis 030211 gastroenterology & hepatology Elastography business Pancreas Tumor Identification |
| Zdroj: | Advances in Medicine and Medical Research ISBN: 9783030129224 |
| DOI: | 10.1007/5584_2018_303 |
| Popis: | The study aimed to determine the usefulness of the elastography in the diagnosis of malignancy of solid pancreatic tumors. There were 123 patients (F/M; 51/72, aged 62 ± 14) enrolled into the study with the diagnosis of pancreatic masses. Malignant pancreatic adenocarcinoma was identified in 78 patients and an inflammatory mass corresponding to chronic pancreatitis in the remaining 45 patients. The mass elasticity of a tumor (A–elasticity) and a reference zone (B–elasticity) and the B/A strain ratio were measured. All these elastographic parameters differed between groups and correlated significantly with malignancies (r = 0.841; r = −0.834; r = 0.487, respectively). Receiver operating characteristic (ROC) analysis showed that A–elasticity between 0.05% and 0.14% alone, as well as the B/A strain ratio between 7.87 and 18.23 alone, enabled the recognition of all malignant pancreatic tumors with 100% sensitivity and ≥ 97.8% specificity. Surprisingly, B–elasticity alone also was helpful in recognizing malignant tumors (71% sensitivity, 80% specificity, 0.74 accuracy, and 0.792 area under the curve), although it appeared worse than A–elasticity and B/A strain ratio (p < 0.001). In multivariable regression analysis, A–elasticity identified 89.5% of malignancies (p < 0.001). A–elasticity and B–elasticity were the only significant independent factors influencing the tumor identification (r2 = 0.927; p < 0.001). The assessment of tumor elasticity appears sufficient to identify malignant tumors of the pancreas. |
| Databáze: | OpenAIRE |
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