STUDIES OF THE BIOLOGICAL ACTIVITY OF CERTAIN 19-NOR STEROIDS IN FEMALE ANIMALS1

Autor:	Gregory Pincus, E. S. E. Hafez, Anne P. Merrill, M. C. Chang, M. X. Zarrow
Rok vydání:	1956
Předmět:	Chinchilla medicine.medical_specialty biology business.industry media_common.quotation_subject Research methodology Biological activity Health services Endocrinology Internal medicine biology.animal medicine Endocrine system business Ovulation Testosterone media_common Hormone
Zdroj:	Endocrinology. 59:695-707
ISSN:	1945-7170 0013-7227
DOI:	10.1210/endo-59-6-695
Popis:	IN PREVIOUS publications a number of compounds have been demonstratedas inhibitors of ovulation in rabbits and rats (1, 2, 3). As ourstandard of reference we have used progesterone, which appears to beeffective also in women (4,5). Of especial interest are four compounds:17a-ethinyl-19-nortestosterone (I), 17a-ethinyl-5(10)estraen-17/3-ol-3-one(II), 17a-ethyl-19-nortestosterone (III), and 17a-methyl-19-nortestosterone (IV). These compounds have been suudied for: (a) progestational activity inrabbits, (b) deciduomagenic capacity in rats, (c) estrogenic activity, (d)ovulation-inhibiting activity in rabbits and rats, and (e) effects on developmentof the ovulated ovum. Progestational activity in rabbits The progestational activity of the various compounds was tested by theClauberg (6) method. Immature, grey Chinchilla, female rabbits weighingapproximately 1 kg. were used in this study.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f93feebcfd2ae0f78ba78862e43edb46 https://doi.org/10.1210/endo-59-6-695 Zobrazit plný text záznamu