Comparative Genome-Wide Association Studies in Mice and Humans for Trimethylamine N-Oxide, a Proatherogenic Metabolite of Choline and L-Carnitine

Autor: Tang, W. H. W., Allayee, H., Lusis, A. J., Roberts, R., McPherson, R., Wang, Z., Bennett, B. J., Stewart, A. F. R., Hartiala, J., Hazen, S. L.
Jazyk: angličtina
Rok vydání: 2014
DOI: 10.17615/r6hc-3s06
Popis: Elevated levels of plasma trimethyl amine N-oxide (TMAO), the product of gut microbiome and hepatic-mediated metabolism of dietary choline and L-carnitine, have recently been identified as a novel risk factor for the development of atherosclerosis in mice and humans. The goals of this study were to identify the genetic factors associated with plasma TMAO levels.
Databáze: OpenAIRE