Predictive and prognostic potential of pretreatment 68Ga-PSMA PET tumor heterogeneity index in patients with metastatic castration-resistant prostate cancer (mCRPC)

Autor: Majid Assadi, Reyhaneh Manafi-Farid, Esmail Jafai, Ahmad Keshavarz, GhasemAli Divband, Mohammad Mobin Moradi, Zohreh Adinehpour, Rezvan Samimi, Habibollah Dadgar, Benjamin Mayer, Vikas Prasad
Rok vydání: 2023
Předmět:
Zdroj: Journal of Clinical Oncology. 41:200-200
ISSN: 1527-7755
0732-183X
DOI: 10.1200/jco.2023.41.6_suppl.200
Popis: 200 Background: 177Lu-PSMA therapy has been introduced as an effective therapeutic option for metastatic castration resistant prostate cancer (mCRPC). Since about one third of the treated patients show no biochemical response (BCR) after therapy, prediction of treatment outcome is important for patient selection. Therefore, this study was conducted to evaluate to the predictive values of volumetric parameters and radiomic features (RFs) extracted form pretreatment 68Ga-PSMA PET and baseline clinical parameters in response to 177Lu-PSMA therapy. Methods: In this multicenter study, mCRPC patients undergoing 177Lu-PSMA therapy were enrolled from September 2017 to January 2022. The available clinical data of all patients was collected and documented from three different centers. The patients underwent several cycles of therapy. According to the outcome of therapy, the patients were classified into two groups including positive BCR (≥ 50% reduction in the serum PSA value) and negative BCR (< 50%). Sixty-five RFs, eight volumetric parameters and also seventeen clinical parameters were evaluated for prediction of BCR. In addition, the impact of such parameters on overall survival (OS) was evaluated. Results: In this retrospective study, 33 prostate cancer patients with a median age of 69 years (range: 49-89) were enrolled. BCR was observed in 22 cases (66%), and 16 cases (48.5%) died during the follow-up time. The results of Spearman correlation test indicated a significant relationship between BCR and treatment cycle, administered dose, HISTO energy, GLCM entropy, and GLZLM LZLGE (p68Ga-PSMA PET images might be a potential predictive value for response to 177Lu-PSMA therapy in mCRPC; however, further prospective studies need to be carried out to verify these findings.
Databáze: OpenAIRE
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