Aspergillus flavus malignant external otitis in a diabetic patient: case report and literature review
Autor: | Stéphane Bretagne, Véronique Joly, Alexandre Alanio, Maud Pichon, Yazdan Yazdanpanah, Michel Wassef, Sandrine Houzé, Benjamin Verillaud, Nicolas Argy |
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Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Microbiology (medical) medicine.medical_specialty medicine.drug_class medicine.medical_treatment 030106 microbiology Antibiotics Aspergillosis 03 medical and health sciences 0302 clinical medicine Medicine 030212 general & internal medicine Voriconazole Aspergillus biology business.industry Cerebral infarction Immunosuppression General Medicine biology.organism_classification medicine.disease Dermatology Infectious Diseases Otitis Etiology medicine.symptom business medicine.drug |
Zdroj: | Infection. 48:193-203 |
ISSN: | 1439-0973 0300-8126 |
Popis: | Malignant external otitis is an aggressive and potentially life-threatening infection. This rare disorder is typically caused by Pseudomonas aeruginosa and affects almost exclusively elderly diabetic patients. However, fungal malignant external otitis have been identified, especially in immunocompromised hosts. We report a rare case of invasive malignant external otitis caused by Aspergillus flavus in a diabetic patient without other underlying immunosuppression. A review of Aspergillus spp. malignant external otitis since voriconazole became the first line for invasive aspergillosis was performed. A 72-year-old man with diabetes mellitus developed invasive malignant external otitis with a vascular involvement. The patient was treated with empiric courses of antibiotics until a fungal infection was diagnosed. Proven Apsergillus infection was based on histopathological examination and isolation of A. flavus from culture of osteo-meningeal biopsies. Despite optimal antimicrobial therapy with voriconazole, the patient presented with cerebral infarction in the setting of an angioinvasive fungal infection leading to a fatal outcome. From a review of the literature, we found 39 previously published cases of proven Aspergillus spp. malignant external otitis treated with new triazoles. Given our experience and the literature review, a fungal etiology should be considered early in the course of malignant external otitis unresponsive to a conventional broad spectrum antibiotic therapy, with the need for a tissue biopsy to confirm the diagnosis. |
Databáze: | OpenAIRE |
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