D-Dimer Testing within the Routine Clinical Chemistry Profile
| Autor: | C. Bieglmayer, T. C. Vukovich, Ahmad Hamwi |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Pathology biology Plasmin business.industry medicine.medical_treatment Biochemistry (medical) Clinical Biochemistry medicine.disease Gastroenterology Fibrin Latex fixation test Pulmonary embolism Venous thrombosis Internal medicine D-dimer Blood plasma Fibrinolysis medicine biology.protein business medicine.drug |
| Zdroj: | Clinical Chemistry. 44:1557-1558 |
| ISSN: | 1530-8561 0009-9147 |
| DOI: | 10.1093/clinchem/44.7.1557 |
| Popis: | D-Dimer is the term for any of a variety of split products that are derived from fibrin fibrils by the action of the fibrinolytic enzyme plasmin. They occur in the circulation in a wide range of molecular weights and carry various numbers of cross-linked D-domains, called D-Dimers (1). Although no commonly accepted standard is available, D-Dimers can be measured by immunoassays that use specific antibodies against the cross-linked D-domain. The concentration of D-Dimers in the blood plasma is correlated to the activity state of the coagulation and fibrinolytic system (2). D-Dimer testing has been shown to be of value for diagnosis of clinically suspected thromboembolism (2)(3)(4)(5). In a recent meta-analysis (6) including data from 2000 patients with suspected deep venous thrombosis and/or pulmonary embolism, increased D-Dimers as measured by ELISA were found to provide a diagnostic sensitivity of 97% for both diseases. However, the practical diagnostic value of D-Dimer testing by ELISA is limited by the long turnaround time and the special equipment required for the assay. Qualitative or semiquantitative latex agglutination slide-assays are suited for bedside testing, but are not … |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|