Lymphopenia Associated With Adjuvant Chemotherapy After Potentially Curative Surgery for Colorectal Cancer Correlates With Recurrence
| Autor: | Hisashi Nagahara, Tetsuro Ikeya, Hiroshi Ohtani, Kosei Hirakawa, Kiyoshi Maeda, Masatsune Shibutani, Kenji Sugano |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Oncology
medicine.medical_specialty Chemotherapy Colorectal cancer Adjuvant chemotherapy business.industry Lymphocyte medicine.medical_treatment Retrospective cohort study Stage ii medicine.disease Normal group medicine.anatomical_structure Internal medicine medicine Curative surgery Surgery business |
| Zdroj: | International Surgery. 105:146-151 |
| ISSN: | 0020-8868 |
| Popis: | The aim of this retrospective study was to evaluate the prognostic significance of lymphopenia associated with chemotherapy in patients with colorectal cancer who received adjuvant chemotherapy after undergoing potentially curative surgery. Lymphocyte plays an important role in antitumor immunity. Lymphopenia is sometimes induced during the period of adjuvant chemotherapy after potentially curative surgery for colorectal cancer. However, the prognostic significance of lymphopenia associated with chemotherapy is unknown. One hundred fifteen patients who received adjuvant chemotherapy after potentially curative surgery for stage II/III colorectal cancer were enrolled in this study. All patients were classified into 2 groups, the lymphopenia group and the normal group, according to minimum lymphocyte count during the period of adjuvant chemotherapy. Lymphopenia was defined as a lymphocyte count of less than 1000/μL. Lymphopenia associated with chemotherapy was found in 17 of the 115 patients (14.8%). Lymphopenia was associated with a worse disease-free survival (P = 0.018) and overall survival (P = 0.022). Moreover, in a multivariate analysis, lymphopenia associated with chemotherapy was identified to be an independent prognostic factor for disease-free survival (hazard ratio, 2.296; 95% confidence interval, 1.089–4.840; P = 0.029) and overall survival (hazard ratio, 2.995; 95% confidence interval, 1.021–8.790; P = 0.046). Lymphopenia associated with chemotherapy is an independent prognostic factor in patients with colorectal cancer who receive adjuvant chemotherapy after undergoing potentially curative surgery. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|