Conformations of the dermenkephalin backbone in dimethyl sulfoxide solution by a new approach to the solution conformations of flexible peptides
| Autor: | Om Prakash, Victor J. Hruby, Catherine A. Gehrig, Gregory V. Nikiforovich |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
chemistry.chemical_classification
Enkephalin Tetrapeptide Stereochemistry medicine.drug_class Peptide Biological activity General Chemistry Dermorphin urologic and male genital diseases Biochemistry Catalysis chemistry.chemical_compound Colloid and Surface Chemistry chemistry Opioid Opioid receptor medicine Receptor medicine.drug |
| Zdroj: | Journal of the American Chemical Society. 115:3399-3406 |
| ISSN: | 1520-5126 0002-7863 |
| DOI: | 10.1021/ja00062a001 |
| Popis: | Dermenkephalin (DRE, H-Tyr-D-Met-Phe-His-Leu-Met-Asp-NH 2 ), a natural peptide found in frog skin, has high potency and receptor selectivity for δ opioid receptors and has potent in vivo analgesic activity. Structurally the compound is related to both the μ opioid receptor selective dermorphin and the δ opioid receptor selective deltorphins. Interestingly, the N-terminal tetrapeptide of DRE is potent and selective for the μ opioid receptor. Efforts to understand the conformational properties of DRE and their relationships to biological activity are of great importance. We report here a novel approach to analyze conformations of short linear peptides in solution to determine the possible solution conformations of DRE |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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