P155 The microRNA 34 family and its clinical significance in ovarian cancer
| Autor: | H Welponer, S Wenzel, AG Zeimet, Verena Wieser, C Degasper, I Tsibulak, C Marth, Susanne Sprung, Giridhar Shivalingaiah, H Fiegl |
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| Rok vydání: | 2019 |
| Předmět: |
Oncology
medicine.medical_specialty business.industry medicine.disease law.invention medicine.anatomical_structure Downregulation and upregulation law Internal medicine microRNA medicine Overall survival Suppressor Clinical significance Progression-free survival Ovarian cancer business Fallopian tube |
| Zdroj: | Poster exhibition Day 2. |
| Popis: | Introduction/Background The tumor suppressor miR-34 family is transcriptionally induced by p53. Clinical significance of the various miR-34 family members has not been studied in ovarian cancer. Methodology In 228 ovarian cancers and in 19 non-neoplastic fallopian tube samples we analysed miR-34a/b/c expression in relation to clinicopathological characteristics and clinical outcome. Results We found significantly lower levels of miR-34a/b/c in ovarian cancers as compared to control-tissues (P=0.002, P Conclusion Our findings suggest that downregulation of miR-34 family is a crucial part in ovarian cancer development. Low miR-34 levels are linked to a worse overall survival and progression free survival and may indicate a more aggressive disease. Disclosure Nothing to disclose. |
| Databáze: | OpenAIRE |
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