Failure to Transmit Carcinogenic Agents from the Pregnant Mouse Embryos in utero
| Autor: | Clarence Cook Little, S. G. Warner |
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| Rok vydání: | 1935 |
| Předmět: | |
| Zdroj: | Experimental Biology and Medicine. 32:866-869 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-32-7890 |
| Popis: | Several investigators have reported transmission in mice of carcinogenic agents from mother to embryo. One group of such investigators believes that a mash of embryos which have developed in the body of a cancerous mother, can transmit cancer on transplantation in other mice. A diagram of this type of relationship is given in Fig. 1.It is evident that if a highly specific and effective degree of carcinogenic activity were transmitted in the way described it would be definite proof of the existence of such an agent smaller than and separable from the cell. Since the larger mass of evidence in rodent tumors argues against the probability that such a condition exists, it seemed worth while to make certain experiments along this line.As far as possible the technique described by Tesauro1 was followed.In any mice which showed masses at the site of transplanted embryonic tissue, observations by palpation were made at frequent intervals. The size of masses was indicated by an outline of their approximate area re... |
| Databáze: | OpenAIRE |
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