Interaction of dimethyltin(IV) dichloride with 5′-IMP and 5′-UMP
| Autor: | Mahla Zandevakili, Fatemeh Jaberi, Farrokh Gharib |
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| Rok vydání: | 2008 |
| Předmět: |
Aqueous solution
Pyrimidine Inorganic chemistry Potentiometric titration General Chemistry Phosphate Medicinal chemistry Inorganic Chemistry chemistry.chemical_compound Trigonal bipyramidal molecular geometry chemistry Ionic strength Stability constants of complexes Fourier transform infrared spectroscopy |
| Zdroj: | Applied Organometallic Chemistry. 22:215-220 |
| ISSN: | 1099-0739 0268-2605 |
| DOI: | 10.1002/aoc.1374 |
| Popis: | The formation constants of the species formed in the systems H+ + dimethyltin(IV) + 5′-IMP and 5′-UMP, H+ + 5′-IMP and H+ + 5′-UMP have been determined in aqueous solution in the pH range 1.5–9.5 at constant temperature (25 °C) and constant ionic strength (0.1 mol dm−3 NaClO4), using spectrophotometric and potentiometric techniques. 1H and 31P NMR investigations in aqueous solution confirmed the species formation. The precipitated complexes of IMP and UMP by Me2Sn(IV)2+ at low pH values were characterized by elemental analysis and FTIR spectroscopy methods, the bonding sites of the ligands were determined and ruled out purine and pyrimidine moieties (N-7 and N-1 in IMP and N-3 in UMP, respectively) while a bidentated coordination of the phosphate group is concluded in both cases. Finally, the experiments revealed the existence of complexes with trigonal bipyramidal structures that is in agreement with similar systems resulted previously. Copyright © 2008 John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
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