Quasielastic light-scattering studies on human fibrinogen and fibrin. II. Fibrin polymerization
| Autor: | O. G. Fritz, G. R. Palmer |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
chemistry.chemical_classification
biology Diffusion Organic Chemistry Size-exclusion chromatography Biophysics Analytical chemistry Rotational diffusion General Medicine Polymer Fibrinogen Biochemistry Fibrin Light scattering Biomaterials Crystallography chemistry Polymerization medicine biology.protein medicine.drug |
| Zdroj: | Biopolymers. 18:1659-1672 |
| ISSN: | 1097-0282 0006-3525 |
| DOI: | 10.1002/bip.1979.360180706 |
| Popis: | The shape of fibrin intermediate polymers as well as the rate of fibrinogen polymerization was studied using diffusion measured by quasielastic light scattering. After their length distribution was narrowed by gel filtration, the polymers yielded translational and rotational diffusion coefficients of 0.37 ± 0.05 × 10−7 cm2 sec−1 and 142 ± 32 sec−1, respectively. Theoretical considerations indicated the polymers to be rigid rods. The rate of polymerization of fibrinogen monitored by diffusion paralleled that provided by simulataneous intensity measurements. Both monitors indicated polymerization occurs most rapidly at 30°C. |
| Databáze: | OpenAIRE |
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