Synthesis and biological evaluation of the potent isoxazolidinyl angiotensin II receptor antagonist CL332,877 and its enantiomers

Autor:	A. Cobuzzi, Jeremy Ian Levin, G. Vice, L. Thibault, A.M. Venkatesan, Fong Lai, Peter S. Chan, T. K. Bailey, Noel Mellish, Joseph Coupet
Rok vydání:	1994
Předmět:	Chemistry Organic Chemistry Clinical Biochemistry Pharmaceutical Science Angiotensin II receptor antagonist Pharmacology Biochemistry In vitro In vivo Drug Discovery Molecular Medicine Enantiomer Molecular Biology Biological evaluation
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 4:1709-1714
ISSN:	0960-894X
DOI:	10.1016/s0960-894x(00)80366-2
Popis:	An alternative synthesis of CL332,877, a potent isoxazolidinyl-quinazolinone angiotensin II receptor antagonist, is described. In addition, the enantiomers of CL332,877 were separated and evaluated both in vitro and in vivo.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f90095b7fd813a3d84997c77d6215924 https://doi.org/10.1016/s0960-894x(00)80366-2 Zobrazit plný text záznamu