Epidemiological study of gastro-oesophageal reflux disease: reflux in spouse as a risk factor

Autor: R. Habibi, K. Rafat‐Zand, Hadi Razjouyan, M.‐H. Ghotbi, Reza Malekzadeh, A.‐R. Ramard, A. Mofid, Mehdi Nouraie, Siavosh Nasseri-Moghaddam, H. Zaer‐Rezaie
Rok vydání: 2008
Předmět:
Zdroj: Alimentary Pharmacology & Therapeutics. 28:144-153
ISSN: 1365-2036
0269-2813
Popis: Summary Background Gastro-oesophageal reflux disease (GERD) is a growing health-care problem with variable distribution. Aim To assess GERD prevalence and risk factors and their possible correlation with pathophysiology in a population-based study. Methods Individuals aged 18–65 years were enrolled through random cluster sampling in Tehran. Previously validated self-administered questionnaires were used. Results Of the 2500 questionnaires, 2057 were analysed (mean age: 34.8 ± 13.0 years, 55.1% female). Frequent GERD was seen in 18.2%. Minor symptoms increased prevalence. Female gender (OR: 1.55, 95% CI: 1.01–2.41), BMI >30 kg/m2 (OR: 1.79, 95% CI: 1.03–3.12), less education (OR: 1.52, 95% CI: 1.02–2.27), smoking (OR: 1.83, 95% CI: 1.12–2.99), NSAID use (OR: 4.23, 95% CI: 1.66–10.74) and GERD in spouse (OR: 1.82, 95% CI: 1.18–2.82) were associated with frequent GERD on multivariable analysis. GERD in first-degree relatives (OR: 1.73, 95% CI: 1.23–2.43) and asthma (OR: 4.09, 95% CI: 1.27–13.15) correlated with infrequent GERD. Minor symptoms correlated with GERD history in first-degree relatives, coffee consumption and NSAID use. Prevalence in the past 3 months was similar to that in the past 12 months (P
Databáze: OpenAIRE
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