| Autor: |
Marie Bettonville, Patricia Vandevenne, Merry Van Puyvelde, Michel Y Braun, Kathleen Weatherly, Haifa Hamdi, Alessandro Zucchi, Jinyu Zhang |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
European Journal of Immunology. 45:829-842 |
| ISSN: |
0014-2980 |
| DOI: |
10.1002/eji.201445066 |
| Popis: |
T cells chronically stimulated by a persistent antigen often become dysfunctional and lose effector functions and proliferative capacity. To identify the importance of micro-RNA-155 (miR-155) in this phenomenon, we analyzed mouse miR-155-deficient CD4(+) T cells in a model where the chronic exposure to a systemic antigen led to T-cell functional unresponsiveness. We found that miR-155 was required for restoring function of T cells after programmed death receptor 1 blockade. Heme oxygenase 1 (HO-1) was identified as a specific target of miR-155 and inhibition of HO-1 activity restored the expansion and tissue migration capacity of miR-155(-/-) CD4(+) T cells. Moreover, miR-155-mediated control of HO-1 expression in CD4(+) T cells was shown to sustain in vivo antigen-specific expansion and IL-2 production. Thus, our data identify HO-1 regulation as a mechanism by which miR-155 promotes T-cell-driven inflammation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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