Syntheses and Characterization of Poly(cyclohexyl vinyl ether-stat-vinyl alcohol)-b-polyisobutylene-b-poly(cyclohexyl vinyl ether-stat-vinyl alcohol) Triblock Copolymers and Their Application as Coatings To Deliver Paclitaxel from Coronary Stents
| Autor: | Robert E. Richard, Rudolf Faust, Yonghua Zhou, Marlene Schwarz |
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| Rok vydání: | 2005 |
| Předmět: |
Vinyl alcohol
Polymers and Plastics Organic Chemistry Vinyl ether Inorganic Chemistry Solvent chemistry.chemical_compound Hildebrand solubility parameter chemistry Polymer chemistry Materials Chemistry medicine Copolymer Organic chemistry Reactivity (chemistry) Thermoplastic elastomer Solubility medicine.drug |
| Zdroj: | Macromolecules. 38:8183-8191 |
| ISSN: | 1520-5835 0024-9297 |
| Popis: | Novel ABA-type thermoplastic elastomers, poly(vinyl alcohol) (PVA)-b-polyisobutylene (PIB)-b-PVA triblock copolymers, were prepared by hydrolysis of poly(tert-butyl vinyl ether) (PtBVE)-b-PIB-b-PtBVE triblock copolymers. Attempts to dissolve the triblocks in a variety of solvents and solvent mixtures for solution casting remained unsuccessful due to the large difference in the solubility parameters of PVA and PIB. To decrease crystallinity and increase the solubility of the end segments, cyclohexyl vinyl ether (CHVE) was copolymerized with tBVE. According to the reactivity ratios determined by the Kelen−Tudos method (rCHVE = 1.37; rtBVE = 0.65), the product poly(CHVE-stat-tBVE) was highly random. Well-defined P(CHVE-stat-tBVE)-b-PIB-b-P(CHVE-stat-tBVE) triblock copolymers (PDI = ∼1.10) were prepared with various CHVE/tBVE ratios. After hydrolysis, the P(CHVE-stat-VA)-b-PIB-b-P(CHVE-stat-VA) triblock copolymers exhibited various amounts of coupled products irrespective of the end block composition and exte... |
| Databáze: | OpenAIRE |
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