Release Testing of Selected Drugs from Surface Magnetic Nanoparticles and Their Diffusion Through a Membrane

Autor:	Jacek J. Kozioł, Alicja Defort, Ewelina Gronczewska, Weronika Worobiec, Andrzej Jurkowski
Rok vydání:	2018
Předmět:	Pharmacology Drug Chemistry Diffusion media_common.quotation_subject 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology Ibuprofen 01 natural sciences 0104 chemical sciences Dialysis tubing law.invention chemistry.chemical_compound Membrane Dextran Chemical engineering Confocal microscopy law Drug Discovery medicine Magnetic nanoparticles 0210 nano-technology medicine.drug media_common
Zdroj:	Pharmaceutical Chemistry Journal. 52:257-265
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-018-1803-8
Popis:	In this study, magnetic nanoparticles were functionalized with dextran and immobilized ibuprofen, diclofenac, and dopamine in order to investigate the diffusion of drugs through a dialysis membrane under biological conditions such as a temperature of 37.0°C and pH 7.4. The concentration of released drugs was measured both inside the membrane and upon release into solution using spectrofluorimetric and spectrophotometric methods. The mechanism of drug release from the carrier was analyzed in terms of the Korsmeyer – Peppas model. The results show that differences in the mechanism of drug release depend on the time-diffusion process and the type of drug used. In addition, the atomic force microscopy and confocal microscopy methods were used to investigate the interaction between bacterial cells and functionalized nanoparticles.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f8ce6497ed46828d333e27eae9256769 https://doi.org/10.1007/s11094-018-1803-8 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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