Cell proliferation and apoptosis immunolocalisation suggest an association between aggressiveness and the preferred location of mural unicystic ameloblastomas: A multicentricStudy

Autor: Rebeca Vieira Costa, Karolyny Martins Balbinot, Gabriela Cristina Avertano Rocha da Silveira, Maria Sueli da Silva Kataoka, Silvio Augusto Fernandes Menezes, Vanessa Morais Freitas, Ana Carolina Uchoa Vasconcelos, Adriana Etges, Fabricio Passador Santos, Sérgio Melo Alves Júnior, Ruy Gastaldoni Jaeger, João de Jesus Viana Pinheiro
Rok vydání: 2023
DOI: 10.21203/rs.3.rs-2652916/v1
Popis: Objectives This study aimed to assess whether the different biological behaviour between subtypes of unicystic ameloblastoma (UA) are related to the expression of proteins that modulate cell proliferation and apoptosis. Materials and methods Immunohistochemical study with a sample of 32 cases of UA, 11 cases of conventional ameloblastoma (CAM) and 10 dental follicles (DF) cases was performed. Cell proliferation was assessed using Ki-67 status and apoptosis by expression of Caspase-3. Positive cells were quantified in each sample and the difference among groups was compared. Results Mural UA (MUA) showed a higher immunostaining of Ki-67 (p
Databáze: OpenAIRE