The metal- and column-free synthesis of pyridin-2-yl ureas carrying cyclic secondary amine substituents and establishing the mechanism of the reactions through a computational study
| Autor: | Kai Liu, Yayu Xie, Yuan Qin, Virinder S. Parmar, Yonghong Liu, Pei Cao |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Organic Chemistry Frontiers. |
| ISSN: | 2052-4129 |
| DOI: | 10.1039/d3qo00571b |
| Popis: | Pyridyl ureas as potential ASK1 inhibitors were synthesized through auto-tandem rearrangement and subsequent one-pot aminolysis involving a more accessible concerted pathway. |
| Databáze: | OpenAIRE |
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