A New Versatile Synthesis of Ring‐Substituted 2‐Cyclopropylglycines and Related Amino Acids

Autor:	Dahai Yu, Norbert Krass, Armin de Meijere, Ludger A. Wessjohann
Rok vydání:	1992
Předmět:	Inorganic Chemistry chemistry.chemical_classification chemistry.chemical_compound Nucleophile chemistry Glycine Organic chemistry Azide Ring (chemistry) Alkyl Amino acid Catalysis
Zdroj:	Chemische Berichte. 125:867-882
ISSN:	0009-2940
Popis:	Alkyl 2-chloro-2-cyclopropylideneacetates 2 serve as universal starting materials for a new general synthesis of cyclopro-pylglycines by a simple three- to four-step methodology. 1,4-Addition of nucleophiles, substitution with azide ion, and mild catalytic deprotection lead to a variety of salt-free cyclopropyl-substituted amino acids in good yields, including the natural products 2-(1-methylcyclopropyl)glycine (4) and cleonin (5).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f8968ac8c7597ae3cf3128c1570a046a https://doi.org/10.1002/cber.19921250418 Zobrazit plný text záznamu Plný text