| Autor: |
J. Casper Swarte, Tim J. Knobbe, Johannes Björk, Ranko Gacesa, Lianne M. Nieuwenhuis, Shuyan Zhang, Arnau Vich Vila, Daan Kremer, Rianne M. Douwes, Adrian Post, Evelien E. Quint, Robert A. Pol, Bernadien Jansen, Martin de Borst, Vincent de Meijer, Hans Blokzijl, Stefan Berger, Eleonora Festen, Alexandra Zhernakova, Jingyuan Fu, Hermie Harmsen, Stephan Bakker, Rinse Weersma |
| Rok vydání: |
2023 |
| DOI: |
10.21203/rs.3.rs-2578408/v1 |
| Popis: |
Kidney transplant recipients (KTR) have impaired health-related quality of life (HRQoL) and suffer from intestinal dysbiosis. Increasing evidence shows that gut health and HRQoL are tightly related in the general population. We investigated the association between the gut microbiome and HRQoL in KTR, using metagenomic sequencing data from fecal samples collected from 507 KTR. Multiple bacterial species were associated with lower HRQoL, many of which have previously been associated with adverse health conditions. Gut microbiome dissimilarity to the general population was highest among KTR with an impaired physical HRQoL (R=-0.20, P=2.3x10-5) and mental HRQoL (R=-0.14, P=1.3x10-3). Physical and mental HRQoL explained a significant part of the variance in the gut microbiome (R2=0.63%, FDR=5.40x10-4 and R2=0.37%, FDR=1.40x10-3, respectively). Additionally, multiple metabolic and neuroactive pathways (gut brain modules) were associated with lower HRQoL. These results put forward the microbiome as a potential target to improve HRQoL in KTR. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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