Gene copy number variation and pediatric mental health/neurodevelopment in a general population
| Autor: | Mehdi Zarrei, Christie L Burton, Worrawat Engchuan, Edward J Higginbotham, John Wei, Sabah Shaikh, Nicole M Roslin, Jeffrey R MacDonald, Giovanna Pellecchia, Thomas Nalpathamkalam, Sylvia Lamoureux, Roozbeh Manshaei, Jennifer Howe, Brett Trost, Bhooma Thiruvahindrapuram, Christian R Marshall, Ryan K C Yuen, Richard F Wintle, Lisa J Strug, Dimitri J Stavropoulos, Jacob A S Vorstman, Paul Arnold, Daniele Merico, Marc Woodbury-Smith, Jennifer Crosbie, Russell J Schachar, Stephen W Scherer |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Human Molecular Genetics. |
| ISSN: | 1460-2083 0964-6906 |
| DOI: | 10.1093/hmg/ddad074 |
| Popis: | We assessed the relationship of gene copy number variation (CNV) in mental health/neurodevelopmental traits and diagnoses, physical health and cognition in a community sample of 7100 unrelated children and youth of European or East Asian ancestry (Spit for Science). Clinically significant or susceptibility CNVs were present in 3.9% of participants and were associated with elevated scores on a continuous measure of attention-deficit/hyperactivity disorder (ADHD) traits (P = 5.0 × 10−3), longer response inhibition (a cognitive deficit found in several mental health and neurodevelopmental disorders; P = 1.0 × 10−2) and increased prevalence of mental health diagnoses (P = 1.9 × 10−6, odds ratio: 3.09), specifically ADHD, autism spectrum disorder anxiety and learning problems/learning disorder (P’s |
| Databáze: | OpenAIRE |
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