Dinucleotide repeat polymorphisms within the Flt-1 gene in minimal change nephropathy

Autor: Peter W. Mathieson, R. G. Parry, A. G. B. Clark, Kathleen M Gillespie
Rok vydání: 1999
Předmět:
Zdroj: European Journal of Immunogenetics. 26:321-323
ISSN: 0960-7420
DOI: 10.1046/j.1365-2370.1999.00161.x
Popis: Dysregulation of Flt-1, a major receptor for vascular permeability factor (VPF), may provide a mechanism for the development of proteinuria in minimal change nephropathy (MCN). The gene for Flt-1 has a polymorphic dinucleotide repeat. We have demonstrated an 88% predominance of one allele and an 80% rate of homozygosity for this polymorphism with no association with MCN.
Databáze: OpenAIRE