Doppler velocimetry and small for gestational age pregnancies in sickle cell disease associated with abnormal placental pathology

Autor:	Akolisa Anyaegbunam, C. A. Axiotis, R. Halpert, Irwin R. Merkatz, Oded Langer, Lois Brustman
Rok vydání:	1991
Předmět:	Pregnancy medicine.medical_specialty biology business.industry Obstetrics Cell Diastole Obstetrics and Gynecology Disease Laser Doppler velocimetry medicine.disease Fibrin medicine.anatomical_structure medicine Placental pathology biology.protein Small for gestational age business
Zdroj:	Journal of Obstetrics and Gynaecology. 11:400-404
ISSN:	1364-6893 0144-3615
Popis:	SummaryPlacentas from singleton deliveries of 108 prospectively followed pregnant women, 18 with sickle cell disease (16 SS, 2 SC) 36 with AS and 54 with AA haemoglobin were examined and findings correlated with antepartum Doppler results and neonatal outcome. Systolic/diastolic ratios ⩾3 were designated as abnormal. Gross and microscopical examinations of placentas were done by a pathologist blinded to the Doppler results and pregnancy outcome.Results of our study show moderate to severe villous sclerosis as well as intervillous fibrin deposits in 31 per cent (5/16) of SS placentas examined but these were absent in the placentas of SC, AS and AA patients. The same patients with sickle cell (SS) disease demonstrated both abnormal uterine and umbilical systolic/diastolic ratios. Four of these five pregnancies resulted in the births of small for dates babies. In contrast, the nine SS women with normal Doppler studies and the two patients with only an abnormal uterine Doppler had normal or minimal placental ...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f884dd9373ab82f222b0cd0b1e905277 https://doi.org/10.3109/01443619109013577 Zobrazit plný text záznamu