Effect of the season on lipid peroxidation in the myocardium of rats with different resistance to hypoxia
| Autor: | L. B. Pirogova, M. L. Khachatur'yan, M. V. Bilenko, P. G. Komarov, V. M. Gukasov |
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| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
Antioxidant Adult male medicine.medical_treatment General Medicine Biology Hypoxia (medical) General Biochemistry Genetics and Molecular Biology Lipid peroxidation Summer season High resistance chemistry.chemical_compound Endocrinology Acute hypoxia chemistry Biochemistry Internal medicine Catecholamine medicine medicine.symptom medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 120:733-736 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/bf02444675 |
| Popis: | Lipid peroxidation and the antioxidant system of the myocardium of adult male Wistar rats with low and high resistance to acute hypoxia tested by “raising” to an altitude of 11.5 km are studied in winter and in summer. It is found that the winter season is a mild stressor inducing changes in the myocardial antioxidant system and lipid peroxidation which are similar to those observed at the early stages of catecholamine stress in the summer season. In both cases alterations are more pronounced in low-resistance than in high-resistance rats. In winter, in low-resistance rats the intensity of lipid peroxidation and the activity of the antioxidant system are lower, while the ratio of their parameters (chemiluminescence data) is higher. At the same time, the levels of thiobarbituric acid-reactive substances are higher in winter in both groups. The relationship between the studied parameters and the resistance of rats to hypoxia is more obvious in winter than in summer, i.e., it is season-dependent and is also more pronounced in catecholamine stress. |
| Databáze: | OpenAIRE |
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