Chiral resolution of the enantiomers of phenylglycinol using (S)-di-naphthylprolinol calix[4]arene by capillary electrophoresis and fluorescence spectroscopy

Autor:	Teresa Grady, Malcolm R. Smyth, Stephen J. Harris, Tom Joyce, Dermot Diamond
Rok vydání:	1998
Předmět:	chemistry.chemical_compound Capillary electrophoresis Capillary column Chemistry Stereochemistry Calixarene Fluorescence spectrometry Enantiomer Derivative (chemistry) Chiral resolution Fluorescence spectroscopy Analytical Chemistry
Zdroj:	Analytical Communications. 35:123-125
ISSN:	1364-5536 1359-7337
DOI:	10.1039/a802025f
Popis:	We have previously shown that the tetra-(S)-di-2-naphthylprolinol calix[4]arene derivative possesses the ability to provide chiral discrimination between enantiomers of phenylethylamine and norephedrine, using fluorescence quenching experiments and Stern–Volmer plots. In this paper, we demonstrate that the same compound interacts selectively with enantiomers of phenylglycinol, using the same approach. We also show that this chiral discrimination can provide efficient separation of phenylglycinol by capillary electrophoresis through the immobilisation of the calix[4]arene on the capillary wall. The results obtained by both methods suggest that the (R)-phenylglycinol enantiomer interacts more strongly with the chiral calixarene than the (S)-enantiomer.
Databáze:	OpenAIRE
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