Alternatively Spliced Variants of Gallus gallus TNFRSF23 Are Expressed in the Ovary and Differentially Regulated by Cell Signaling Pathways1

Autor:	Alan L. Johnson, Jamie T. Bridgham
Rok vydání:	2004
Předmět:	Genetics Expressed sequence tag Messenger RNA Stromal cell Ovary Cell Biology General Medicine Biology Cell biology medicine.anatomical_structure Reproductive Medicine Apoptosis medicine Signal transduction Receptor Death domain
Zdroj:	Biology of Reproduction. 70:972-979
ISSN:	1529-7268 0006-3363
DOI:	10.1095/biolreprod.103.023614
Popis:	As a result of searching recently available chicken (ch) expressed sequence tag databases, a new Tumor Necrosis Factor Receptor Super Family (TNFRSF) member with similarity to the murine (m) TNFRSF23 decoy receptor (DcR) has been identified. However, by comparison with the mTNFRSF23, there exist at least two splice variants of chTNFRSF23, one of which includes an intracellular death domain (TNFRSF23.v1) characteristic of death receptors, and the other with a truncated cytoplasmic domain of a DcR (named TNFRSF23.v2). These two splice variants of chTNFRSF23 display differential patterns of mRNA expression across various hen tissues, with the highest levels observed within reproductive tissues. More specifically, TNFRSF23.v1 is most highly expressed in preovulatory follicle granulosa cells in the ovary, whereas TNFRSF23.v2 mRNA is found at highest levels in ovarian stromal tissue. Primary culture experiments with granulosa cells determined that expression of TNFRSF23.v1 mRNA was decreased by protein...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f87fdfb3d3576e4dbbd513657faa38a6 https://doi.org/10.1095/biolreprod.103.023614 Zobrazit plný text záznamu