C-erbB-2 immunoexpression in parathyroid tumors and hyperplasias
| Autor: | Luciana N. C. Martin, José Gilberto H. Vieira, Vânia Nosé, M. J. Kayath |
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| Rok vydání: | 1999 |
| Předmět: |
Calcium metabolism
Hyperparathyroidism medicine.medical_specialty Pathology Parathyroid neoplasm business.industry Endocrinology Diabetes and Metabolism Intact parathyroid hormone C erb b 2 Normal tissue General Medicine medicine.disease Pathology and Forensic Medicine Pathogenesis Parathyroid tumors Endocrinology Internal medicine medicine business |
| Zdroj: | Endocrine Pathology. 10:47-54 |
| ISSN: | 1559-0097 1046-3976 |
| DOI: | 10.1007/bf02738815 |
| Popis: | C-erbB-2 is a proto-oncogene previously implicated in the pathogenesis and prognosis of several human tumors. The authors investigated c-erbB-2 immunoexpression in parathyroid tumors and hyperplasias, and correlated its presence with the diagnosis and severity of the parathyroid lesions. One hundred two parathyroid tissues (28 adenomas, 12 primary hyperplasias, 57 secondary hyperplasias, and 5 carcinomatous tissues) were studied. Membrane c-erbB-2 (either in the cell membrane or on the border of pseudocysts) was absent in normal glands, and detected in 50% of the adenomas, 25% of the primary hyperplasias, 100% of the carcinomas, and 12 and 53% of the secondarily diffuse and nodular hyperplasias, respectively. C-erbB-2 expression was significantly lower in diffuse hyperplasias than in other parathyroid lesions (P |
| Databáze: | OpenAIRE |
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