Approaches to p-hydroxyphenoxymethylquinolines which avoid intermediate chloromethylquinolines for the synthesis of the LTD4 antagonist, RG 12525

Autor:	Adam W. Sledeski, Larry K. Truesdale, Michael K. O'Brien
Rok vydání:	1997
Předmět:	chemistry.chemical_compound chemistry Stereochemistry Organic Chemistry Drug Discovery Antagonist Phenol Sulfate Biochemistry
Zdroj:	Tetrahedron Letters. 38:509-512
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(96)02361-1
Popis:	As part of an effort to develop an industrial synthesis of the LTD4 antagonist RG 12525 (1), several approaches to the intermediate (2-quinolinylmethoxy)phenol 3 were investigated that avoided the generation of the lachrymatory sensitizer α-chloro-2-methylquinoline 2. Utilization of a cyclic sulfate in place of α,α′-dichloro-o-xylene 4 showed promise as a selective dialkylating agent in the conversion of 3 to RG 12525 (1).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f87460f3d0c1866ab35a103321ee4d9c https://doi.org/10.1016/s0040-4039(96)02361-1 Zobrazit plný text záznamu Full Text from ScienceDirect