Direct C-H Arylation of Heteroarenes with Aryl Chlorides by Using an Abnormal N-Heterocyclic-Carbene-Palladium Catalyst
| Autor: | Pradip Kumar Hota, Gonela Vijaykumar, Samaresh Chandra Sau, Swadhin K. Mandal, Pavan K. Vardhanapu, Jasimuddin Ahmed, Sreejyothi P |
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| Rok vydání: | 2017 |
| Předmět: |
010405 organic chemistry
Aryl Organic Chemistry 010402 general chemistry Furfural 01 natural sciences Chloride 0104 chemical sciences Catalysis chemistry.chemical_compound chemistry Furan medicine Thiophene Organic chemistry Physical and Theoretical Chemistry Carbene Palladium catalyst medicine.drug |
| Zdroj: | European Journal of Organic Chemistry. 2017:1004-1011 |
| ISSN: | 1434-193X |
| DOI: | 10.1002/ejoc.201601218 |
| Popis: | Herein, we report a versatile catalytic system for the direct C–H arylation of heteroarenes with activated aryl chloride substrates. The catalyst works successfully for a variety of heteroarenes and aryl chloride coupling partners under very low catalyst-loading conditions. We have successfully performed the direct C–H arylations of 1-methylpyrrole, 1-methylindole, furan, thiophene, furfural, and N-benzyl-1,2,3-triazole with aryl chloride partners in good yields without the use of any additives. Furthermore, we used this catalytic process to develop a one-pot synthetic protocol for the muscle relaxant dantrolene on a gram scale. Additionally, the present catalytic system can be used to perform consecutive arylations in one pot. |
| Databáze: | OpenAIRE |
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