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hypertension free of overt cardiovascular complications. In 171 untreated, grade 1-2, hypertensive patients (age 49 13 yr.; 92 males) we measured anthropometric variables, plasma biochemistries, glomerular filtration rate (GFR), PA and active renin, and assessed by conventional and tissue Doppler (TDI) echocardiography the morphology of the LV and variables of LV diastolic function (E/A, e-wave velocity, e/ a and E/ e ratio). LV diastolic dysfunction with a pattern of abnormal relaxation was detected by TDI echocardiography in 101 patients (59%) who were older, more frequently males and diabetics, and had higher body mass index (BMI), systolic blood pressure (SBP), and LV mass index, and lower PA levels (134 77 pg/ml) than patients with preserved LV diastolic function (168 94 pg/ml, P1⁄40.014). Variables of diastolic function measured both at conventional and TDI echocardiography were significantly related to increasing age, BMI, duration of hypertension, and LV mass index and to decreasing GFR (Table). TDI e-wave velocity was also directly related to SBP and PA levels and its relationship with age (b1⁄4-0.436, P |
