Cytotoxic potential and antiparasitic activity of the Croton rhamnifolioides Pax leaves. & K. Hoffm essential oil and its inclusion complex (EOCr/β-CD)
| Autor: | Miriam Rolón, Almir Gonçalves Wanderley, Anita Oliveira Brito Pereira Bezerra Martins, Henrique Douglas Melo Coutinho, Ana Carolina Justino de Araújo, Isabel Sousa Alcântara, Adriano Antunes de Souza Araújo, Maria Rayane Correia de Oliveira, Maria Celeste Vega Gomez, Priscilla Ramos Freitas, Cathia Coronel, Lucindo José Quintans Júnior, Irwin Rose Alencar de Menezes |
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| Rok vydání: | 2021 |
| Předmět: |
Polymers and Plastics
Antiparasitic medicine.drug_class 02 engineering and technology 010402 general chemistry 01 natural sciences law.invention law Materials Chemistry medicine Medicinal plants IC50 Essential oil biology Traditional medicine Chemistry General Chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics biology.organism_classification Antiparasitic agent Leishmania braziliensis Croton 0104 chemical sciences Leishmania infantum 0210 nano-technology |
| Zdroj: | Polymer Bulletin. 79:1175-1185 |
| ISSN: | 1436-2449 0170-0839 |
| Popis: | Leishmaniasis and Chagas disease are neglected tropical diseases with relevance and public interest. Currently, the search for antiparasitic agents from medicinal plants has been the target of great research. Croton rhamnifolioides Pax. & K. Hoffm is known in popular medicine as “quebra-faca” or “caatinga-branca” and is used to treat stomachache, vomiting and fever. The aim of this study was to evaluate the cytotoxic potential and antiparasitic activity of the Croton rhamnifolioides Pax leaves. & K. Hoffm essential oil (EOCr) and its inclusion complex with β-cyclodextrin (EOCr/β-CD). The trypanocide, leishmanicidal and cytotoxicity activity investigations were performed in triplicates by in vitro cell culture assays using different EOCr (1000, 500, 250, 125, 62.5 μg/mL) and EOCr/β-CD (1000, 500 and 250 μg/mL) concentrations dissolved in dimethyl sulfoxide. The results showed the EOCr and EOCr/β-CD possessed an inhibitory potential with IC50 values of 85.21 and 1823 μg/mL against T. cruzi, IC50 values of 127.43 and 354.568 μg/mL against Leishmania braziliensis and IC50 values of 111.84 and 923.56 μg/mL against Leishmania infantum, respectively, with the EOCr being the most effective against T. cruzi. The EOCr presented toxic effects against NCTC929 fibroblasts at the highest concentrations of 1000 and 500 μg/mL, obtaining an IC50 value of 338.84 μg/mL; however, the EOCr/β-CD showed no signs of significant cytotoxicity obtaining an IC50 greater than 1000 μg/mL. The current results suggest the C. rhamnifolioides essential oil presents significant results, thus representing an alternative source for the development of natural products with antiparasitic activity. |
| Databáze: | OpenAIRE |
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