| Autor: |
Thi H. O. Nguyen, Nicholas Coatsworth, Teresa Neeman, Jin-Shu He, Sarah M. Hicks, Florian Kurth, Kate M Parsons, Ian A. Cockburn, Hayley A. McNamara, Graham J. Mann, Carola G. Vinueas, Amee J George, Sidra A Ali, Samina Nazir, Kai Pohl, Elizabeth E. Gardiner, Louise C. Rowntree, Paul S. Myles, Leif E. Sander, Denise L. Doolan, Katherine Kedzierska, Matthew C. Cook, Russell L. Gruen |
| Rok vydání: |
2020 |
| Předmět: |
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| Popis: |
Estimates of seroprevalence of SARS-CoV-2 antibodies have been hampered by inadequate assay sensitivity and specificity. Using an ELISA-based approach to that combines data about IgG responses to both the Nucleocapsid and Spike-receptor binding domain antigens, we show that near-optimal sensitivity and specificity can be achieved. We used this assay to assess the frequency of virus-specific antibodies in a cohort of elective surgery patients in Australia and estimated seroprevalence in Australia to be 0.28% (0 to 0.72%). These data confirm the low level of transmission of SARS-CoV-2 in Australia before July 2020 and validate the specificity of our assay. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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