Severe serotoninergic syndrome after ingestion of α-methyltryptamine
| Autor: | Séverine Férec, Chloé Bruneau, Isabelle Leborgne, Joanna Bourgine, Alain Turcant, Bénédicte Lelièvre, Marie Bretaudeau-Deguigne, Xavier Valette, David Boels, Chadi Abbara |
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| Rok vydání: | 2016 |
| Předmět: |
Health
Toxicology and Mutagenesis Toxicology 01 natural sciences law.invention 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine law medicine Mydriasis Ingestion 030216 legal & forensic medicine Creatinine biology business.industry 010401 analytical chemistry Glasgow Coma Scale medicine.disease Intensive care unit 0104 chemical sciences Respiratory acidosis chemistry Anesthesia biology.protein Creatine kinase medicine.symptom business Methadone medicine.drug |
| Zdroj: | Toxicologie Analytique et Clinique. 28:71-78 |
| ISSN: | 2352-0078 |
| Popis: | Summary Alpha-methyltryptamine (AMT) is an analogue of endogenous tryptamine with psychotropic effects and is available on the web as designer drug or new psychoactive substance (NPS). A clinical case of a severe serotoninergic syndrome after ingestion of this substance is reported. The patient (male, 33 years), known as autist and poly-addict with a substitution treatment by methadone, was admitted at hospital (H0) for agitation. Tablets found in a bag at home should be methoxphenidine (MXP). Clinical symptoms suggested serotoninergic syndrome with Glasgow Score 10/15, diaphoresis, mydriasis, hyperthermia and tachycardia (140 beats/min). The major hyperthermia (42 °C) needed to transfer the patient in an intensive care unit (H4). The biological constants showed metabolic and respiratory acidosis with pH at 7.28, PaCO 2 6.5 kPa and lactates at 3.7 mmol/L. Creatinine was 156 μmol/L (325 on day D2), creatine phosphokinase (CPK) was 1973 U/L (26,895 on D2), ASAT and ALAT enzymes were at 75 N on D2 with prothrombin time |
| Databáze: | OpenAIRE |
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