Autor: |
Gerald S Rork, Alexander E. Forbes, Davar Khossravi, David Slade, John L. Haslam, Theresa L Pipkin |
Rok vydání: |
1998 |
Předmět: |
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Zdroj: |
International Journal of Pharmaceutics. 173:233-242 |
ISSN: |
0378-5173 |
Popis: |
Controlled release enalapril millispheres of different diameters were prepared and tableted with excipients in a 1:1 ratio on a Carver press. Drug release rate profiles showed that the microporous coating on the millispheres was severely damaged during the compression process. Overcoating of the microporous coating with hydroxypropyl methylcellulose E5 (HPMC E5) protects the microporous coating during compression by absorbing and dissipating the compressional forces. This protection becomes more pronounced as the size of the millispheres is reduced. A novel investigation of individual millisphere strength was conducted to identify the most favorable coating and size combination which would preserve the controlled release properties of the millispheres. |
Databáze: |
OpenAIRE |
Externí odkaz: |
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