Tableting of controlled release multiparticulates, the effect of millisphere size and protective overcoating

Autor:	Gerald S Rork, Alexander E. Forbes, Davar Khossravi, David Slade, John L. Haslam, Theresa L Pipkin
Rok vydání:	1998
Předmět:	Chemistry Stereochemistry Drug release rate Pharmaceutical Science Microporous material engineering.material Compression (physics) Controlled release Dosage form Tableting Coating engineering Particle size Composite material
Zdroj:	International Journal of Pharmaceutics. 173:233-242
ISSN:	0378-5173
Popis:	Controlled release enalapril millispheres of different diameters were prepared and tableted with excipients in a 1:1 ratio on a Carver press. Drug release rate profiles showed that the microporous coating on the millispheres was severely damaged during the compression process. Overcoating of the microporous coating with hydroxypropyl methylcellulose E5 (HPMC E5) protects the microporous coating during compression by absorbing and dissipating the compressional forces. This protection becomes more pronounced as the size of the millispheres is reduced. A novel investigation of individual millisphere strength was conducted to identify the most favorable coating and size combination which would preserve the controlled release properties of the millispheres.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f864cb51154686318ddc709333ef0a89 https://doi.org/10.1016/s0378-5173(98)00240-3 Zobrazit plný text záznamu Full Text from ScienceDirect