GOLD Classifications, COPD Hospitalization, and All-Cause Mortality in Chronic Obstructive Pulmonary Disease: The HUNT Study
| Autor: | Laxmi Bhatta, Linda Leivseth, Yue Chen, Arnulf Langhammer, Xiao-Mei Mai, Anne Hildur Henriksen, David Carslake, Ben Michael Brumpton |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
COPD Receiver operating characteristic business.industry Pulmonary disease General Medicine medicine.disease Obstructive lung disease 3. Good health 03 medical and health sciences 0302 clinical medicine 030228 respiratory system Internal medicine Hunt study Area under curve medicine 030212 general & internal medicine business All cause mortality Survival analysis |
| Zdroj: | International Journal of Chronic Obstructive Pulmonary Disease. 15:225-233 |
| ISSN: | 1178-2005 |
| Popis: | Purpose The Global Initiative for Chronic Obstructive Lung Disease (GOLD) has published three classifications of COPD from 2007 to 2017. No studies have investigated the ability of these classifications to predict COPD-related hospitalizations. We aimed to compare the discrimination ability of the GOLD 2007, 2011, and 2017 classifications to predict COPD hospitalization and all-cause mortality. Patients and methods We followed 1300 participants with COPD aged ≥40 years who participated in the HUNT Study (1995-1997) through to December 31, 2015. Survival analysis and time-dependent area under receiver operating characteristics curves (AUC) were used to compare the discrimination abilities of the GOLD classifications. Results Of the 1300 participants, 522 were hospitalized due to COPD and 896 died over 20.4 years of follow-up. In adjusted models, worsening GOLD 2007, GOLD 2011, or GOLD 2017 categories were associated with higher hazards for COPD hospitalization and all-cause mortality, except for the GOLD 2017 classification and all-cause mortality (ptrend=0.114). In crude models, the AUCs (95% CI) for the GOLD 2007, GOLD 2011, and GOLD 2017 for COPD hospitalization were 63.1 (58.7-66.9), 60.9 (56.1-64.4), and 56.1 (54.0-58.1), respectively, at 20-years' follow-up. Corresponding estimates for all-cause mortality were 57.0 (54.8-59.1), 54.1 (52.1-56.0), and 52.6 (51.0-54.3). The differences in AUCs between the GOLD classifications to predict COPD hospitalization and all-cause mortality were constant over the follow-up time. Conclusion The GOLD 2007 classification was better than the GOLD 2011 and 2017 classifications at predicting COPD hospitalization and all-cause mortality. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|