Antitumor activity of Corynebacterium parvum administered into the pleural cavity of mice
| Autor: | Luka Milas, B. Malenica, I. Basic, N. Vujičić |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Cancer Research
Chemotherapy Pathology medicine.medical_specialty Lung business.industry medicine.medical_treatment Immunology Pleural cavity Pharmacology medicine.disease medicine.anatomical_structure Oncology Immunity Corynebacterium parvum Concomitant medicine Immunology and Allergy Neoplasm Fibrosarcoma business |
| Zdroj: | Cancer Immunology Immunotherapy. 7:107-115 |
| ISSN: | 1432-0851 0340-7004 |
| DOI: | 10.1007/bf00205332 |
| Popis: | We investigated the efficacy of intrapleurally (IPl) injected 0.25 mg Corynebacterium parvum (CP) against pulmonary tumor deposits of four syngeneic murine tumors, C3Hf/Bu or CBA fibrosarcoma (FSa) or mammary carcinoma (MCa), and compared its efficacy with that of intravenous (IV) CP. A mode of action of CP given by IPl administration was also studied. When given to mice prior to the IV inoculation of tumor cells, IPl and IV CP reduced the number of metastases of C3Hf/Bu-FSa and CBA-MCa equally well. Intrapleural injection of CP within a week after tumor cell inoculation was more effective against metastases in the lung than IV CP. A combination of IPl and IV administration of CP was more effective in the therapy of lung metastases of CBA-FSa and CBA-MCa than either single treatment alone. Intrapleural and IV injections of CP augmented concomitant immunity to artificially produced lung metastases of C3Hf/Bu-FSa. Intrapleural CP was less effective than IV CP in inducing complete regression of the SC growing C3Hf/Bu-FSa. |
| Databáze: | OpenAIRE |
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