An efficient and convenient method for synthesizing new derivatives of pyrido[2,3-e]pyrrolo[1,2-a][1,4]diazepine-5,10-dione via Sonogashira, Suzuki–Miyaura, and Stille cross-coupling reactions

Autor:	Mina Aadil, Ahmed El Hakmaoui, Said Lazar, Marie-Claude Viaud-Massuard, Mohamed Akssira, Abderrahman El Bouakher, Gildas Prie
Rok vydání:	2012
Předmět:	chemistry.chemical_compound Diazepine chemistry Organic Chemistry Drug Discovery Sonogashira coupling Biochemistry Combinatorial chemistry Coupling reaction Stille reaction
Zdroj:	Tetrahedron Letters. 53:6401-6405
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2012.09.041
Popis:	An efficient method for synthesizing new pyrido[2,3-e]pyrrolo[1,2-a][1,4]diazepine-5,10-dione derivatives starting from l -proline methyl ester and 2-aminonicotinic acid is presented. This method employs Pd-catalyzed cross-coupling reaction on the corresponding brominated compound 4 (key intermediate). Sonogashira, Stille, and Suzuki–Miyaura cross-coupling reactions are used to generate products 5a–g, 6, 7a–c, and 8a–e, in good to excellent yields.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f85e78594c2db57d786a695aaca86e00 https://doi.org/10.1016/j.tetlet.2012.09.041 Zobrazit plný text záznamu Full Text from ScienceDirect