| Autor: | Deng K. Niu, Jia-Kuan Chen |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Mathematical and theoretical biology
Programmed cell death Applied Mathematics Somatic hypermutation General Medicine Biology medicine.disease_cause General Biochemistry Genetics and Molecular Biology Cell biology Philosophy Apoptosis medicine General Agricultural and Biological Sciences Carcinogenesis Gene General Environmental Science |
| Zdroj: | Acta Biotheoretica. 46:379-381 |
| ISSN: | 0001-5342 |
| DOI: | 10.1023/a:1001803420183 |
| Popis: | With a previous paper (Niu & Wang, 1995), a general, hypothetical outline of the mechanism of carcinogenesis was proposed. With reference to the fact of starvation-induced hypermutation in micro-organisms, we propose that the hypoxia commonly seen in the cells at the centre of solid tumours might also result in hypermutation, and then p53-dependent programmed cell death. Like the apparently adaptive mutations in micro-organisms, only those genes (e.g. p53) that enable the cells to escape from apoptosis may be selected. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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