Insulin Degludec/Insulin Aspart Administered Once Daily at Any Meal, With Insulin Aspart at Other Meals Versus a Standard Basal-Bolus Regimen in Patients With Type 1 Diabetes
| Autor: | Patrik Dykiel, Henriette Mersebach, Bruce W. Bode, Edward Franek, Melanie J. Davies, Irl B. Hirsch, J.-P. Courreges, Kjeld Hermansen, Allen B King |
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| Rok vydání: | 2012 |
| Předmět: |
Advanced and Specialized Nursing
Insulin degludec medicine.medical_specialty Type 1 diabetes business.industry Endocrinology Diabetes and Metabolism Insulin medicine.medical_treatment medicine.disease Gastroenterology Insulin aspart Endocrinology Tolerability Internal medicine Diabetes mellitus Internal Medicine medicine business Insulin detemir medicine.drug Glycemic |
| Zdroj: | Diabetes Care. 35:2174-2181 |
| ISSN: | 1935-5548 0149-5992 |
| DOI: | 10.2337/dc11-2503 |
| Popis: | OBJECTIVE To evaluate efficacy and tolerability of a co-formulation of insulin degludec and insulin aspart (IDegAsp) with insulin aspart (IAsp) at other meals compared with basal-bolus therapy using insulin detemir (IDet) and IAsp. RESEARCH DESIGN AND METHODS Adults (n = 548) with type 1 diabetes (A1C 7.0–10.0%; BMI ≤35.0 kg/m2) were randomized 2:1 in a 26-week, multinational, parallel-group, treat-to-target trial to IDegAsp or IDet. IDegAsp was given with a meal, and IDet was given in the evening, with a second (breakfast) dose added if needed. RESULTS Non-inferiority for IDegAsp versus IDet was confirmed; A1C improved by 0.75% with IDegAsp and 0.70% with IDet to 7.6% in both groups (estimated treatment difference IDegAsp − IDet: –0.05% [95% CI –0.18 to 0.08]). There was no statistically significant difference between IDegAsp and IDet in the rates of severe hypoglycemia (0.33 and 0.42 episodes/patient-year, respectively) or overall confirmed (plasma glucose CONCLUSIONS IDegAsp in basal-bolus therapy with IAsp at additional mealtimes improves overall glycemic control and was non-inferior to IDet, with a reduced risk of nocturnal hypoglycemia and fewer injections in comparison with IDet + IAsp basal-bolus therapy. |
| Databáze: | OpenAIRE |
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